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Cell line expression
Protein structure
RB1
RB transcriptional corepressor 1OSRC, PPP1R130, RB
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-11387 |
22 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| antibodies-online | ABIN266998 |
2 references | Monoclonal |
WB
ICC
IP
IHC
FC
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| Proteintech Group | 10048-2-Ig |
38 references | Polyclonal |
WB
EL
IP
IHC
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| Cell Signaling Technology, Inc | 9309 |
1 references | Monoclonal |
WB
ICC
IP
IHC
FC
ChIP
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| GeneTex | GTX100545 |
2 references | Polyclonal |
WB
ICC
IP
IHC
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