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IGF1R
Insulin like growth factor 1 receptorCD221, IGFIR, IGFR, JTK13, MGC18216
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Top validated antibodies |
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| R&D Systems |  MAB391-100 |
15 references | Monoclonal |
WB
EL
ICC
IHC
FC
BN
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| Proteintech Group | 20254-1-AP |
47 references | Polyclonal |
WB
EL
IP
IHC
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| Novus Biologicals | AF-305-NA |
9 references | Polyclonal |
WB
ICC
IHC
BN
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| LSBio | LS-C180145 |
Polyclonal |
WB
ICC
IHC
|
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| antibodies-online | ABIN259940 |
8 references | Monoclonal |
WB
EL
IHC
FC
|
|
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