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Protein structure
MBD1
Methyl-CpG binding domain protein 1CXXC3, PCM1
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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| Novus Biologicals |  NB100-56537 |
9 references | Monoclonal |
WB
ICC
IP
IHC
ChIP
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| LSBio | LS-C133910 |
Monoclonal |
WB
EL
IHC
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| antibodies-online | ABIN393589 |
6 references | Monoclonal |
WB
EL
IHC
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| Abcepta | AT2811a |
1 references | Monoclonal |
WB
EL
IHC
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| Abnova Corporation | H00004152-B01 |
2 references | Polyclonal |
WB
ICC
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