Tissue expression
Cell line expression
Protein structure
MBD1
Methyl-CpG binding domain protein 1CXXC3, PCM1
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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Novus Biologicals | NB100-56537 | 9 references | Monoclonal |
WB
ICC
IP
IHC
ChIP
|
|
antibodies-online | ABIN393589 | 6 references | Monoclonal |
WB
EL
IHC
|
|
LSBio | LS-C133910 | Monoclonal |
WB
EL
IHC
|
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Invitrogen Antibodies | MA1-41025 | Monoclonal |
WB
ICC
IP
IHC
ChIP
|
||
Abgent | AT2811a | 1 references | Monoclonal |
WB
EL
IHC
|
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