NR1I2

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

Description

Nuclear receptor subfamily 1 group I member 2

Tissue specificity

Group enriched (intestine, liver)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors
Transporters

Chromosome

3 (119780484 - 119818487)

Ensembl ID

ENSG00000144852  (ver. 103.38)

Orthologs

Mouse Nr1i2: ENSMUSG00000022809

UniProt

O75469

neXtProt

NX_O75469

Human splice variants
Mouse splice variants

Protein structure