Tissue expression
Cell line expression
Protein structure
RUBCN
Rubicon autophagy regulatorKIAA0226, rubicon, rundataxin
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Top validated antibodies |
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LSBio | LS-C774354 | Polyclonal |
WB
ICC
IHC
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Proteintech Group | 21444-1-AP | 7 references | Polyclonal |
WB
EL
IHC
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Abgent | AP1831a | Polyclonal |
WB
ICC
IHC
FC |
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NSJ Bioreagents | F54720 | Polyclonal |
WB
ICC
IHC
FC |
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Invitrogen Antibodies | PA5-38017 | 1 references | Polyclonal |
WB
ICC
IHC
|
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