SLC17A4

Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]). [supplied by OMIM, Feb 2011]

Description

Solute carrier family 17 member 4

Tissue specificity

Group enriched (gallbladder, intestine, liver, pancreas)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Transporters

Chromosome

6 (25754699 - 25781199)

Ensembl ID

ENSG00000146039  (ver. 103.38)

Orthologs

Mouse Slc17a4: ENSMUSG00000021336

UniProt

Q9Y2C5

neXtProt

NX_Q9Y2C5

Human splice variants
Mouse splice variants

Protein structure