RNF217

This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Description

Ring finger protein 217

Tissue specificity

Tissue enhanced (parathyroid gland)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

6 (124962545 - 125092633)

Ensembl ID

ENSG00000146373  (ver. 103.38)

Orthologs

Mouse Rnf217: ENSMUSG00000063760

UniProt

Q8TC41

neXtProt

NX_Q8TC41

Human splice variants
Mouse splice variants

Protein structure