RGS20

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Description

Regulator of G protein signaling 20

Tissue specificity

Tissue enhanced (brain, retina)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

8 (53851795 - 53959303)

Ensembl ID

ENSG00000147509  (ver. 103.38)

Orthologs

Mouse Rgs20: ENSMUSG00000002459

UniProt

O76081

neXtProt

NX_O76081

Human splice variants
Mouse splice variants

Protein structure