MAL2

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

Description

Mal, T cell differentiation protein 2

Tissue specificity

Tissue enhanced (esophagus)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

8 (119165034 - 119245673)

Ensembl ID

ENSG00000147676  (ver. 103.38)

Orthologs

Mouse Mal2: ENSMUSG00000024479

UniProt

Q969L2

neXtProt

NX_Q969L2

Human splice variants
Mouse splice variants

Protein structure