DPH7

Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]

Description

Diphthamide biosynthesis 7

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (137554444 - 137578925)

Ensembl ID

ENSG00000148399  (ver. 103.38)

Orthologs

Mouse Dph7: ENSMUSG00000026975

UniProt

Q9BTV6

neXtProt

NX_Q9BTV6

Human splice variants
Mouse splice variants

Protein structure