VAX1

This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of body development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeobox gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Ventral anterior homeobox 1

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoplasm, Nucleoli rim

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

10 (117128521 - 117138301)

Ensembl ID

ENSG00000148704  (ver. 103.38)

Orthologs

Mouse Vax1: ENSMUSG00000006270

UniProt

Q5SQQ9

neXtProt

NX_Q5SQQ9

Human splice variants
Mouse splice variants

Protein structure