GRIK4

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Description

Glutamate ionotropic receptor kainate type subunit 4

Tissue specificity

Tissue enhanced (brain)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

11 (120511746 - 120988906)

Ensembl ID

ENSG00000149403  (ver. 103.38)

Orthologs

Mouse Grik4: ENSMUSG00000032017

UniProt

Q16099

neXtProt

NX_Q16099

Human splice variants
Mouse splice variants

Protein structure