WWC2

This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]

Description

WW and C2 domain containing 2

Tissue specificity

Low tissue specificity

Subcell location

Microtubules

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (183099257 - 183320777)

Ensembl ID

ENSG00000151718  (ver. 103.38)

Orthologs

Mouse Wwc2: ENSMUSG00000031563

UniProt

Q6AWC2

neXtProt

NX_Q6AWC2

Human splice variants
Mouse splice variants

Protein structure