AP1S3

This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Description

Adaptor related protein complex 1 subunit sigma 3

Tissue specificity

Tissue enhanced (epididymis)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (223751686 - 223838027)

Ensembl ID

ENSG00000152056  (ver. 103.38)

Orthologs

Mouse Ap1s3: ENSMUSG00000054702

UniProt

Q96PC3

neXtProt

NX_Q96PC3

Human splice variants
Mouse splice variants

Protein structure