MEPE

This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Description

Matrix extracellular phosphoglycoprotein

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (87821411 - 87846817)

Ensembl ID

ENSG00000152595  (ver. 103.38)

Orthologs

Mouse Mepe: ENSMUSG00000053863

UniProt

Q9NQ76

neXtProt

NX_Q9NQ76

Human splice variants
Mouse splice variants

Protein structure