Tissue expression
Cell line expression
Protein structure
UTRN
UtrophinDMDL, DRP, DRP1
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Biorbyt | orb2205619 | Polyclonal |
WB
ICC
IP
IHC |
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NSJ Bioreagents | RQ6404 | Polyclonal |
WB
EL
ICC
|
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Boster Biological Technology | A02194-1 | Polyclonal |
WB
EL
ICC
|
||
Novus Biologicals | H00007402-M01 | Monoclonal |
WB
EL
ICC
|
||
FineTest Biotech | FNab10379 | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider