FBXL2

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Description

F-box and leucine rich repeat protein 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (33277025 - 33403662)

Ensembl ID

ENSG00000153558  (ver. 103.38)

Orthologs

Mouse Fbxl2: ENSMUSG00000032507

UniProt

Q9UKC9

neXtProt

NX_Q9UKC9

Human splice variants
Mouse splice variants

Protein structure