HS3ST3A1

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]

Description

Heparan sulfate-glucosamine 3-sulfotransferase 3A1

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Microtubules

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

17 (13494032 - 13601929)

Ensembl ID

ENSG00000153976  (ver. 103.38)

Orthologs

Mouse Hs3st3a1: ENSMUSG00000047759

UniProt

Q9Y663

neXtProt

NX_Q9Y663

Human splice variants
Mouse splice variants

Protein structure