CEP112

This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Description

Centrosomal protein 112

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Midbody ring, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (65635537 - 66192133)

Ensembl ID

ENSG00000154240  (ver. 103.38)

Orthologs

Mouse Cep112: ENSMUSG00000020728

UniProt

Q8N8E3

neXtProt

NX_Q8N8E3

Human splice variants
Mouse splice variants

Protein structure