Tissue expression
Cell line expression
Protein structure
OBSCN
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFARHGEF30, KIAA1556, KIAA1639, UNC89
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Atlas Antibodies | HPA021186 | Polyclonal |
ICC
IHC |
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Cusabio Biotech Co., Ltd | CSB-PA729422LA01HU | Polyclonal |
EL
ICC
IHC
|
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Biorbyt | orb423091 | Polyclonal |
EL
ICC
IHC
|
||
antibodies-online | ABIN2565742 | Monoclonal |
WB
EL |
||
Invitrogen Antibodies | PA5-54345 | Polyclonal |
ICC
IHC |
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