DPH3

This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]

Description

Diphthamide biosynthesis 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

3 (16257061 - 16264969)

Ensembl ID

ENSG00000154813  (ver. 103.38)

Orthologs

Mouse Dph3: ENSMUSG00000021905

UniProt

Q96FX2

neXtProt

NX_Q96FX2

Human splice variants
Mouse splice variants

Protein structure