TYSND1

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Description

Trypsin like peroxisomal matrix peptidase 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (70137981 - 70146700)

Ensembl ID

ENSG00000156521  (ver. 103.38)

Orthologs

Mouse Tysnd1: ENSMUSG00000020087

UniProt

Q2T9J0

neXtProt

NX_Q2T9J0

Human splice variants
Mouse splice variants

Protein structure