ADGRG4

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

Description

Adhesion G protein-coupled receptor G4

Tissue specificity

Tissue enhanced (fallopian tube, intestine, retina)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

X (136300963 - 136416890)

Ensembl ID

ENSG00000156920  (ver. 103.38)

Orthologs

Mouse Adgrg4: ENSMUSG00000053852

UniProt

Q8IZF6

neXtProt

NX_Q8IZF6

Human splice variants
Mouse splice variants

Protein structure