CD1B

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]

Description

CD1b molecule

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Golgi apparatus, Vesicles, Cytosol

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (158327951 - 158331531)

Ensembl ID

ENSG00000158485  (ver. 103.38)

Orthologs

-

UniProt

P29016

neXtProt

NX_P29016

Human splice variants

Protein structure