CES5A

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Description

Carboxylesterase 5A

Tissue specificity

Tissue enriched (epididymis)

Predicted location

Intracellular, Secreted in male reproductive system

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

16 (55846154 - 55956031)

Ensembl ID

ENSG00000159398  (ver. 103.38)

Orthologs

Mouse Ces5a: ENSMUSG00000058019

UniProt

Q6NT32

neXtProt

NX_Q6NT32

Human splice variants
Mouse splice variants

Protein structure