TOR2A

This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis of atherosclerosis. The antimicrobial peptide salusin-beta has antibacterial activity. [provided by RefSeq, Nov 2014]

Description

Torsin family 2 member A

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Plasma membrane

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (127731524 - 127735313)

Ensembl ID

ENSG00000160404  (ver. 103.38)

Orthologs

Mouse Tor2a: ENSMUSG00000009563

UniProt

Q8N2E6, Q5JU69

neXtProt

NX_Q8N2E6, NX_Q5JU69

Human splice variants
Mouse splice variants

Protein structure