PPP1R16A

Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]

Description

Protein phosphatase 1 regulatory subunit 16A

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (144477969 - 144502121)

Ensembl ID

ENSG00000160972  (ver. 103.38)

Orthologs

Mouse Ppp1r16a: ENSMUSG00000033819

UniProt

Q96I34

neXtProt

NX_Q96I34

Human splice variants
Mouse splice variants

Protein structure