SLAMF6

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]

Description

SLAM family member 6

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Plasma membrane, Cytosol

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (160485030 - 160523262)

Ensembl ID

ENSG00000162739  (ver. 103.38)

Orthologs

Mouse Slamf6: ENSMUSG00000015314

UniProt

Q96DU3

neXtProt

NX_Q96DU3

Human splice variants
Mouse splice variants

Protein structure