S100A9

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]

Description

S100 calcium binding protein A9

Tissue specificity

Group enriched (bone marrow, esophagus, vagina)

Subcell location

Nucleoplasm, Cell Junctions, Cytosol

Predicted location

Intracellular, Secreted to blood

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (153357854 - 153361023)

Ensembl ID

ENSG00000163220  (ver. 103.38)

Orthologs

Mouse Gm5849: ENSMUSG00000096621

UniProt

P06702

neXtProt

NX_P06702

Human splice variants
Mouse splice variants

Protein structure