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LZTFL1
Leucine zipper transcription factor like 1BBS17
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| Proteintech Group |  17073-1-AP |
4 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Novus Biologicals | H00054585-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
PLA
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| Abnova Corporation | H00054585-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C501988 |
Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 17073-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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