Tissue expression
Cell line expression
Protein structure
GPER1
G protein-coupled estrogen receptor 1CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Novus Biologicals | NLS4271 | 14 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Invitrogen Antibodies | PA5-28647 | 4 references | Polyclonal |
WB
ICC
IHC
OA |
|
GeneTex | GTX107748 | 3 references | Polyclonal |
WB
ICC
IHC
|
|
antibodies-online | ABIN441270 | 5 references | Polyclonal |
WB
ICC
IHC
FC |
|
R&D Systems | AF5534 | 1 references | Polyclonal |
WB
IHC
FC
|
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Recommended by provider