AQP7

This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]

Description

Aquaporin 7

Tissue specificity

Tissue enhanced (adipose tissue, breast, heart muscle)

Predicted location

Intracellular, Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

9 (33383179 - 33402682)

Ensembl ID

ENSG00000165269  (ver. 103.38)

Orthologs

-

UniProt

O14520

neXtProt

NX_O14520

Human splice variants

Protein structure