JAM3

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Description

Junctional adhesion molecule 3

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (134069071 - 134152001)

Ensembl ID

ENSG00000166086  (ver. 103.38)

Orthologs

Mouse Jam3: ENSMUSG00000031990

UniProt

Q9BX67

neXtProt

NX_Q9BX67

Human splice variants
Mouse splice variants

Protein structure