ADAMTS15

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 15

Tissue specificity

Tissue enhanced (adipose tissue)

Subcell location

Cytosol

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

11 (130448974 - 130476641)

Ensembl ID

ENSG00000166106  (ver. 103.38)

Orthologs

Mouse Adamts15: ENSMUSG00000033453

UniProt

Q8TE58

neXtProt

NX_Q8TE58

Human splice variants
Mouse splice variants

Protein structure