Tissue expression
Cell line expression
Protein structure
BTRC
Beta-transducin repeat containing E3 ubiquitin protein ligasebeta-TrCP1, betaTrCP, bTrCP, bTrCP1, FBXW1A, Fwd1
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]
Top validated antibodies |
|||||
Invitrogen Antibodies | 37-3400 | 21 references | Monoclonal |
WB
EL
ICC
IP
FC
OA |
|
antibodies-online | ABIN952275 | 4 references | Polyclonal |
WB
ICC
IHC
|
|
LSBio | LS-C682511 | Monoclonal |
WB
EL
IHC
|
||
Novus Biologicals | NBP2-61712 | Monoclonal |
WB
EL
IHC
FC |
||
Acris Antibodies GmbH | AP50408PU-N | Polyclonal |
WB
EL
IHC
FC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider