CLEC4E

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Description

C-type lectin domain family 4 member E

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

12 (8533305 - 8540905)

Ensembl ID

ENSG00000166523  (ver. 103.38)

Orthologs

Mouse Clec4e: ENSMUSG00000030142

UniProt

Q9ULY5

neXtProt

NX_Q9ULY5

Human splice variants
Mouse splice variants

Protein structure