SCG5

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

Description

Secretogranin V

Tissue specificity

Tissue enhanced (pancreas, pituitary gland)

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (32641676 - 32697098)

Ensembl ID

ENSG00000166922  (ver. 103.38)

Orthologs

Mouse Scg5: ENSMUSG00000023236

UniProt

P05408

neXtProt

NX_P05408

Human splice variants
Mouse splice variants

Protein structure