MMP26

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]

Description

Matrix metallopeptidase 26

Tissue specificity

Tissue enriched (endometrium)

Predicted location

Secreted to extracellular matrix

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

11 (4704927 - 4992429)

Ensembl ID

ENSG00000167346  (ver. 103.38)

Orthologs

-

UniProt

Q9NRE1

neXtProt

NX_Q9NRE1

Human splice variants

Protein structure