Tissue expression
Cell line expression
Protein structure
TUBA1A
Tubulin alpha 1aB-ALPHA-1, FLJ25113, TUBA3
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Top validated antibodies |
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Novus Biologicals | NB600-506 | 34 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
FA
RA |
|
antibodies-online | ABIN153391 | 19 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
RA
|
|
Proteintech Group | 66200-1-Ig | 44 references | Monoclonal |
WB
EL
ICC
IHC |
|
Invitrogen Antibodies | PA5-22060 | 7 references | Polyclonal |
WB
ICC
IHC
OA |
|
Boster Biological Technology | A03989-1 | 1 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
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