KRT80

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Description

Keratin 80

Tissue specificity

Tissue enriched (skin)

Subcell location

Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (52168996 - 52192014)

Ensembl ID

ENSG00000167767  (ver. 103.38)

Orthologs

Mouse Krt80: ENSMUSG00000037185

UniProt

Q6KB66

neXtProt

NX_Q6KB66

Human splice variants
Mouse splice variants

Protein structure