SOAT2

Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Description

Sterol O-acyltransferase 2

Tissue specificity

Tissue enriched (intestine)

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (53103486 - 53124535)

Ensembl ID

ENSG00000167780  (ver. 103.38)

Orthologs

Mouse Soat2: ENSMUSG00000023045

UniProt

O75908

neXtProt

NX_O75908

Human splice variants
Mouse splice variants

Protein structure