NLRC3

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Description

NLR family CARD domain containing 3

Tissue specificity

Tissue enhanced (intestine, lymphoid tissue)

Subcell location

Vesicles, Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (3539033 - 3577403)

Ensembl ID

ENSG00000167984  (ver. 103.38)

Orthologs

Mouse Nlrc3: ENSMUSG00000049871

UniProt

Q7RTR2

neXtProt

NX_Q7RTR2

Human splice variants
Mouse splice variants

Protein structure