PTGDR

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Description

Prostaglandin D2 receptor

Tissue specificity

Tissue enhanced (intestine, lymphoid tissue)

Predicted location

Membrane

Protein family

Disease related genes
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins

Chromosome

14 (52267698 - 52276724)

Ensembl ID

ENSG00000168229  (ver. 103.38)

Orthologs

Mouse Ptgdr: ENSMUSG00000071489

UniProt

Q13258

neXtProt

NX_Q13258

Human splice variants
Mouse splice variants

Protein structure