MTNR1A

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

Description

Melatonin receptor 1A

Tissue specificity

Tissue enhanced (brain, intestine, kidney, testis)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

4 (186533655 - 186555567)

Ensembl ID

ENSG00000168412  (ver. 103.38)

Orthologs

Mouse Mtnr1a: ENSMUSG00000054764

UniProt

P48039

neXtProt

NX_P48039

Human splice variants
Mouse splice variants

Protein structure