KCNG4

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel modifier subfamily G member 4

Tissue specificity

Group enriched (brain, retina)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Chromosome

16 (84218667 - 84239750)

Ensembl ID

ENSG00000168418  (ver. 103.38)

Orthologs

Mouse Kcng4: ENSMUSG00000045246

UniProt

Q8TDN1

neXtProt

NX_Q8TDN1

Human splice variants
Mouse splice variants

Protein structure