ATP5ME

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Description

ATP synthase membrane subunit e

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (672436 - 674330)

Ensembl ID

ENSG00000169020  (ver. 103.38)

Orthologs

Mouse Atp5k: ENSMUSG00000050856

UniProt

P56385

neXtProt

NX_P56385

Human splice variants
Mouse splice variants

Protein structure