Tissue expression
Cell line expression
Protein structure
KLK7
Kallikrein related peptidase 7PRSS6, SCCE
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Top validated antibodies |
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Novus Biologicals | AF2624 | 6 references | Polyclonal |
WB
IP
IHC
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R&D Systems | AF2624 | 6 references | Polyclonal |
WB
IP
IHC
|
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Abnova Corporation | PAB4415 | 3 references | Polyclonal |
WB
IHC
FC
|
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antibodies-online | ABIN2840744 | 1 references | Polyclonal |
WB
IHC
FC
|
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Abgent | AP6326b | Polyclonal |
WB
IHC
FC
|
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