Tissue expression
Cell line expression
Protein structure
RGS14
Regulator of G protein signaling 14This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Proteintech Group | 16258-1-AP | 5 references | Polyclonal |
WB
EL
IP
IHC |
|
Invitrogen Antibodies | 16258-1-AP | Polyclonal |
WB
IP
IHC
OA |
||
Abnova Corporation | H00010636-M03 | Monoclonal |
EL
ICC
IHC
|
||
Biorbyt | orb449397 | Polyclonal |
WB
EL
ICC
IHC |
||
Antibodies Incorporated / NeuroMab | 73-170 | Monoclonal |
WB
ICC
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider