PTAFR

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Description

Platelet activating factor receptor

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1 (28147166 - 28193936)

Ensembl ID

ENSG00000169403  (ver. 103.38)

Orthologs

Mouse Ptafr: ENSMUSG00000056529

UniProt

P25105

neXtProt

NX_P25105

Human splice variants
Mouse splice variants

Protein structure