UGP2

The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

UDP-glucose pyrophosphorylase 2

Tissue specificity

Tissue enhanced (liver, tongue)

Subcell location

Nucleoplasm, Centrosome, Mitochondria

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (63840952 - 63891562)

Ensembl ID

ENSG00000169764  (ver. 103.38)

Orthologs

Mouse Ugp2: ENSMUSG00000001891

UniProt

Q16851

neXtProt

NX_Q16851

Human splice variants
Mouse splice variants

Protein structure